Scholarship: Fully-funded
Degree: Bachelor, Master, Ph.D
Nationality: International Students
Location: USA
Application deadlines: Open
Scholarship Description:
The Cui Laboratory in the Department of Biochemistry at the University of Illinois Urbana-Champaign is recruiting postdoctoral associates and graduate students to study the mechanism and regulation of human ribonucleotide reductase (RNR) in vitro and in vivo.
RNR catalyzes the reduction of nucleotides to deoxynucleotides in nearly all organisms, providing essential building blocks for DNA synthesis and repair. Its central role in nucleic acid metabolism makes RNR a promising target for cancer therapeutics and antimicrobial agents. Human RNR consists of dynamic complexes formed by α and β subunits.
Available Subjects:
- Study Fe2-Y• cofactor assembly and repair
- Trap and characterize the active α/β complex
- Target the inactive state for RNR inhibitors
Eligibility criteria:
- Biophysical methods to characterize metalloenzymes
- Kinetic methods to study enzyme mechanisms
- Genetic incorporation of unnatural amino acids
Application Procedure:
Contact information [email protected]
